Drug Uses

Zyban is indicated as an aid to smoking cessation treatment.

How Taken

Zyban comes as a tablet to take it orally. It is usually taken twice a day and may be taken with or without food. It is important to swallow Zyban Tablets whole. Do not chew, divide, or crush tablets.

Warnings/Precautions

Do not take Zyban if you have taken a monoamine oxidase inhibitor (MAOI) in the last 14 days. Zyban is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take Zyban without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Zyban will be harmful to a nursing baby. Do not take Zyban without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you forget to take a dose, do not take an extra tablet to catch up for the dose you forgot. Wait and take your next tablet at the regular time. Do not take more tablets than your doctor prescribed. This is important so you do not increase your chance of having a seizure.

Possible Side Effects

Like all medicines, Zyban may cause side effects. Do not rely on this summary alone for information about side effects. Your doctor can discuss with you a more complete list of side effects that may be relevant to you. Hypertension (high blood pressure), in some cases severe, has been reported when taking Zyban alone and in combination with nicotine replacement therapy (for example a nicotine patch). The most common side effects include dry mouth and difficulty sleeping. These side effects are generally mild and often disappear after a few weeks. If you have difficulty sleeping, avoid taking your medicine too close to bedtime. The most common side effects that stopped taking Zyban during clinical studies were shakiness and skin rash. Stop taking Zyban and contact your doctor or health care professional if you have signs of an allergic reaction such as a rash, hives, or difficulty in breathing. It is not possible to predict whether a mild rash will develop into a more serious reaction. Therefore, if you experience a skin rash, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, or swelling of lips or tongue, tell a doctor immediately, since these symptoms may be the first signs of a serious reaction. Discuss any other troublesome side effects with your doctor.

Storage

Store Zyban at room temperature, out of direct sunlight. Keep Zyban in a tightly closed container. Keep Zyban out of the reach of children.

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of a Zyban overdose include seizures, hallucinations, loss of consciousness, weakness, a fast heartbeat, and heart attack.

More Information

Avoid alcohol or drink it only in moderation while taking Zyban. Alcohol may increase the risk of having a seizure while taking Zyban. However, if you usually drink a lot of alcohol, talk with your doctor before stopping. Suddenly stopping may increase the risk of having a seizure. Talk to your doctor about alcohol use before starting treatment with Zyban. Use caution when driving, operating machinery, or performing other hazardous activities. Zyban may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Highlights
* There are numerous effective smoking cessation methods available in the United States. The methods range from self-help materials, to intensive clinical approaches, to broad community-based programs. Minimal clinical assistance; intensive clinical assistance; and individual, group, or telephone counseling have shown few differences in effectiveness between men and women.
* Studies show no major or consistent differences between women’s and men’s motivation to quit, readiness to quit, general awareness of the harmful health effects of smoking, or the effectiveness of intervention programs for tobacco use.
* Based on national surveys, the probability of attempting to quit smoking and to succeed has been equally high among women and men since the late 1970s or early 1980s.
* The majority of smokers who try to stop using tobacco reported doing so on their own, even though this is the least effective method. This pattern has changed somewhat in recent years with increased use of pharmacologic aids.
* The likelihood of having been counseled to stop smoking was slightly higher for women (39%) than for men (35%); women report more physician visits than men, which allows more opportunity for counseling.
* Intensive clinical interventions involve individual, group, or telephone counseling for multiple sessions. The most successful treatments are multi-component cognitive behavioral programs that incorporate strategies to prepare and motivate smokers to stop smoking.
* Women are somewhat more likely than men to use intensive treatment programs. Similarly, women have a stronger interest than men in smoking cessation groups that offer mutual support through a buddy system and in treatment meetings over a long period.
* A number of effective pharmacotherapies for nicotine addiction have emerged in the past decade—nicotine gum and nicotine patch (approved for over-the-counter use), nicotine nasal spray, oral nicotine inhaler, and Bupropion (available by prescription). Two other pharmacotherapies, Clonidine and the antidepressant Nortiptyline, have been recommended as second-line pharmacotherapies, but have not yet been approved by the Food and Drug Administration for this indication—smoking cessation.
* Pharmacologic approaches to smoking cessation raise a number of issues specific to women. Nevertheless, nicotine replacement has been shown to be more effective than placebo among women smokers and, thus, remains recommended for use.
* More research is needed to determine the effects of nicotine replacement therapy on pregnant women and their offspring.
* Studies have identified numerous gender-related factors that should be studied as predictors for smoking cessation as well as factors for continued smoking or relapse after quitting. These factors include hormonal influences, pregnancy, fear of weight gain, lack of social support, and depression.
* Women stop smoking more often during pregnancy—both spontaneously and with assistance—than at any other time in their lives. However, most women return to smoking after pregnancy: up to 67% are smoking again by 12 months after delivery.
* Pregnancy-specific programs benefit both maternal and infant health and are cost-effective. If the national prevalence of smoking before or during the first trimester of pregnancy were reduced by one percentage point annually, it would prevent 1,300 babies from being born at low birth weight and save $21 million (in 1995 dollars) in direct medical costs in the first year alone. Prenatal smoking cessation interventions can be of economic benefit to healthcare insurers.
* More women than men fear weight gain if they quit smoking; however, few studies have found a relationship between weight gain concerns and smoking cessation among either women or men. Further, actual weight gain during cessation efforts does not predict relapse to smoking.
* Smoking cessation treatment and social support derived from family and friends improve cessation rates. Whether there are gender differences in the role of social support on long-term smoking cessation is inconclusive.
* Women of low socioeconomic status (SES) have lower rates of smoking cessation than do women of higher SES. Studies that analyze the effects of mass media campaigns suggest that smokers of low SES, especially women, are more likely than smokers of high SES to watch and obtain cessation information from television.
* Women of low SES enrolled in intensive cessation intervention programs (stress management, self-esteem enhancement, group support, and other activities that improve quality of life) have 20%–25% successful cessation rates. Unfortunately, only a small proportion of women of low SES appear to take advantage of these programs.
* In general, African-American, Hispanic, and American-Indian or Alaska-Native women want to stop smoking at rates similar to those of white women, but there is little research on smoking cessation among women in racial/ethnic minority populations.
* There is strong scientific evidence that shows increases in state and federal excise taxes on tobacco products reduce consumption and increase the number of people who stop using tobacco. Price increases reduce consumption of tobacco products by adults, young adults, adolescents, and children.
* Mass-media campaigns implemented in combination with other interventions, such as excise tax increases and community education programs, are effective in reducing tobacco consumption and motivating tobacco product users to quit.
* There are a number of effective interventions to help tobacco users in their efforts to quit, such as behavioral programs offering counseling in individual or group settings and the use of a number of pharmacotherapies, including nicotine replacement. One way to increase the use of effective treatments is to lower the cost for people who wish to use these treatments. Scientific evidence shows that interventions that reduce smokers’ costs (such as programs that reduce or eliminate the insured’s copayment) increase the number of people who stop using tobacco products.
* There is no Medicare coverage for tobacco use dependence except in a few states that will participate in a demonstration project starting in April 2001.
* Six states provide Medicaid coverage for counseling, and four states cover all prescription drugs and over-the-counter nicotine replacement products.
* Under private insurance, 42% of managed care organizations (MCOs) cover counseling, 16% cover indemnity counseling, 38% cover drugs, and 25% cover indemnity drugs.

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