Drug Uses

Vaniqa (Cream) is a prescription medication applied to the skin for the reduction of unwanted facial hair in women. Vaniqa interferes with an enzyme found in the hair follicle of the skin needed for hair growth. This results in slower hair growth and improved appearance where Vaniqa is applied. Vaniqa does not permanently remove hair or "cure" unwanted facial hair. It is not a depilatory. Your treatment program should include continuation of any hair removal technique you are currently using. Vaniqa will help you manage your condition and improve your appearance.

How Taken

Apply a thin layer of Vaniqa Cream to affected areas of the face and adjacent involved areas under the chin and rub in thoroughly. Do not wash treated area for at least 4 hours. Use twice daily at least 8 hours apart or as directed by a physician. You should continue to use hair removal techniques as needed in conjunction with Vaniqa. (Vaniqa should be applied at least 5 minutes after hair removal). Cosmetics or sunscreens may be applied over treated areas after cream has dried.

Warnings/Precautions

Do not use Vaniqa if you have had an allergic reaction to it in the past. Vaniqa is in the FDA pregnancy category C. This means that it is not known whether Vaniqa will harm an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant. It is also not known whether Vaniqa passes into breast milk. Do not use Vaniqa without first talking to your doctor if you are breast-feeding a baby. Vaniqa has not been approved for use by children younger than 12 years of age.

Missed Dose

If you forget or miss a dose of Vaniqa do not try to "make it up". Return to your normal application schedule as soon as you can.

Possible Side Effects

Vaniqa may cause temporary redness, stinging, burning, tingling or rash on areas of the skin where it is applied. Hair bumps may also occur. If these persist, consult your doctor. Treatment related skin adverse events that occurred in less than 1% of the subjects treated with Vaniqa are: bleeding skin, cheilitis, and contact dermatitis, swelling of lips, herpes simplex, numbness and rosacea. Adverse events were primarily mild in intensity and generally resolved without medical treatment or discontinuation of Vaniqa.

Storage

Store at 25° C (77° F); excursions permitted to 15° C-30° C (59° F-86° F). Do not freeze. See tube crimp and carton end for expiration date and lot number.

Overdose

An overdose of Vaniqa is not likely to occur. If the cream has been ingested, or if you suspect an overdose has occurred, contact your doctor, hospital emergency room, or poison control center for advice.

More Information

Avoid getting this medication in your eyes, nose, or mouth. If this occurs, wash the area with water. If Vaniqa gets in your eyes, rinse thoroughly with water and contact your doctor.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Uterine Cancer
Also called: Endometrial cancer
The uterus, or womb, is an important female reproductive organ. It is the place where a baby grows when a women is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer.
The symptoms of uterine cancer include
* Unusual vaginal bleeding or discharge
* Trouble urinating
* Pelvic pain
* Pain during intercourse
Uterine cancer usually occurs after menopause. Being obese and taking estrogen-alone hormone replacement therapy also increase your risk. Treatment varies depending on your overall health, how advanced the cancer is and whether hormones affect its growth. Treatment is usually a hysterectomy, which is surgery to remove the uterus. Other options include hormone therapy and radiation.
About the Uterus and Endometrium
The uterus is a hollow organ, about the size and shape of a medium-sized pear. The uterus has two main parts. The lower end of the uterus, which extends into the vagina, is called the cervix. The upper part is the body of the uterus, also known as the corpus. (Corpus is the Latin word for body.) The body of the uterus has two layers. The inner layer is called the endometrium. (endo is Greek for inside and metrium is Greek for uterus.) The outer is called the myometrium. (myo is Greek for muscle.) The myometrium is the thick layer of muscle that pushes the baby out during birth.
Hormone changes during a woman?s menstrual cycle cause the endometrium to change. During the early part of the cycle, the ovaries (glands on either side of the uterus that produce eggs) produce estrogens. This causes the endometrium to thicken in order to nourish an embryo in case the woman becomes pregnant. After an ovary releases an egg (called ovulation), if pregnancy does not occur, estrogen is produced in lower amounts and more progesterone is made. This causes the innermost layer of the lining to prepare to shed. By the end of the cycle, the lining is shed from the uterus and becomes the menstrual flow. This cycle repeats throughout a woman?s life until menopause (change of life).
Cancers of the Uterus and Endometrium
Adenocarcinomas: Nearly all endometrial cancers (about 95%) are cancers of glandular cells, called adenocarcinomas. Most of these are described as typical adenocarcinomas.
Most experts divide endometrial adenocarcinomas into two types. In type 1, the cancer looks most like normal endometrium and may not be a very dangerous, life-threatening cancer. It only occasionally spreads to other tissues. This type is often called endometrioid, meaning it looks like normal endometrial lining tissue. There are three grades of tumor, with grade three being more aggressive with a greater risk of invasion to the uterine wall (myometrium), local and distant metastases.
Sometimes, in addition to glandular cells, endometrial cancers also contain squamous cells (the type of cells found on the surface of the cervix and the skin). If the squamous cells look benign (non-cancerous) under a microscope and the glandular cells look cancerous, these tumors are called adenocarcinomas with squamous differentiation (they used to be called adenoacanthomas, although this term is now used much less often). If the squamous areas and glandular areas both look malignant (cancerous), these tumors are called adenosquamous carcinomas. Although these look different under the microscope, they are treated the same as typical endometrial adenocarcinomas. However, adenosquamous carcinomas tend to be more aggressive.
Type 2 endometrial cancer doesn?t look at all like normal endometrium. It is much more likely to spread and is, therefore, more dangerous, These types are called either papillary serous adenocarcinomas or clear cell adenocarcinomas. About 10% of endometrial cancers are these types. Because they are different from the usual kind and tend to grow and spread they are treated more aggressively than the endometrioid cancers. Women with this type of cancer tend to be older by five to ten years on average, than women with type 1.
Uterine sarcomas: Uterine cancers that do not come from glandular tissue of the endometrium are called uterine sarcomas. They are less common, but can still involve other parts of the endometrium. These include:
* stromal sarcomas, which start in the stroma (supporting connective tissue) of the endometrium
* malignant mixed mesodermal tumors (MMMTs or carcinosarcomas), which may combine features of endometrial carcinoma and those of sarcomas
* leiomyosarcomas, which start in the myometrium or muscular wall of the uterus
These three types of cancer are not discussed in this document because their treatment and prognosis (the outlook for survival) are different from the most common cancers of the endometrium. These cancers are discussed in the document ?Uterine Sarcomas,? which is available from the American Cancer Society upon request or online.
Cervical cancers: Cancers of the cervix are different from cancers of the body of the uterus and are described in another American Cancer Society document.

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