Drug Uses

Ultram is used to relieve moderate to moderately severe pain. It also may be used to treat pain caused by surgery and chronic conditions such as cancer or joint pain. Ultram works by decreasing the brain's perception and response to pain. It also reduces the size or magnitude of the pain signal passed from one nerve to another. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How Taken

Ultram comes as a tablet to take it orally. It usually is taken every 4-6 hours as needed. It may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Ultram exactly as directed. Ultram can be habit-forming. Do not take a larger dose take it more often, or for a longer period than your doctor tells you to.

Warnings/Precautions

Before taking Ultram, tell your doctor if you have kidney disease; liver disease; or a history of alcohol or drug dependence. You may not be able to take Ultram, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Ultram is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is also not known whether Ultram passes into breast milk. Do not take Ultram without first talking to your doctor if you are breast-feeding a baby. If you are over 75 years of age, you may be more likely to experience side effects from Ultram. The maximum daily dose of Ultram for people over 75 years of age is 300 mg. Ultram is not approved by the FDA for use by children younger than 16 years of age.

Missed Dose

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible Side Effects

Although side effects from Ultram are not common, they can occur. The most frequently reported events were in the central nervous system (Migraine, Speech disorders) and gastrointestinal system (Gastrointestinal bleeding, Hepatitis, Stomatitis, Liver failure). Tell your doctor if any of these symptoms are severe or do not go away: dizziness, headache, drowsiness, blurred vision, upset stomach, vomiting, and diarrhea. If you experience any of the following symptoms, call your doctor immediately: fast heartbeat, redness, swelling, and itching of the face, numbness or tingling of the hands and feet, difficulty breathing, changes in urination, seizures.

Storage

Dispense in a tight container. Store at 25°C (77°F); excursions permitted to 15 - 30°C (59 - 86°F).

Overdose

Seek emergency medical attention. Symptoms of a Ultram overdose include difficulty breathing; shallow, weak breathing; and seizures.

More Information

Do not drink alcohol while taking Ultram. Alcohol may cause a dangerous decrease in breathing and/ or liver problems when used during treatment with Ultram. Use caution when driving, operating machinery, or performing other hazardous activities. Ultram may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Avoid sleeping pills, tranquilizers, sedatives, and antihistamines except under the supervision of your doctor. These drugs may increase drowsiness caused by Ultram.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Q: What is your cancellation policy for Ultram?
A: You may cancel your order before the order has shipped or been approved by the doctor. If the order has already been shipped or approved we cannot cancel your order. Please refer to the current cancellation policy in the terms & conditions section of our order page for more information.


The nutritional supplement glucosamine boosts the pain relieving power of ibuprofen, according to a new study by Temple University researchers in the Journal of Pharmacology and Experimental Therapeutics (JPET). This new drug combination could one day allow patients to take a lower dose and get the same pain relief with fewer unwanted side effects. Ronald Tallarida, Ph.D., and Alan Cowan, Ph.D., of Temple's School of Medicine, and Robert Raffa, Ph.D., of Temple's School of Pharmacy, conducted the study "Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice," which was published in the November 2003 issue of JPET. Ibuprofen is a non-steroidal anti-inflammatory drug, or NSAID. NSAIDs, which also include aspirin, are quite effective in relieving pain. They are so effective, in fact, that pain sufferers sometimes take higher and higher doses in hope of more pain relief. High doses of NSAIDs, especially when taken over long periods of time, can cause gastrointestinal upset, such as heartburn, or even bleeding. "Combining pain relievers into one pill can increase patient compliance, simplify prescribing, and improve efficacy without increasing side effects, or conversely, decrease side effects without losing efficacy," said Raffa. In addition to these benefits, drug combinations can also sometimes yield a totally unexpected effect, such as the magnification of a drug's powers. "When this happens, a phenomenon known as drug synergism, it's like finding buried treasure," added Tallarida. Glucosamine, a naturally occurring substance in the body, which is also available in synthetic form over the counter, is used to treat osteoarthritis, a painful, degenerative joint disorder. While it has been shown to prevent and repair bone and cartilage damage, researchers have yet to demonstrate that glucosamine actually blocks pain. "We embarked on this study with several questions: Can glucosamine actually block pain? And, can glucosamine improve the pain-relieving powers of other drugs when the two are combined?" said Tallarida. First, the researchers confirmed that glucosamine, alone, does not block pain. It's believed that any pain-relieving properties of glucosamine are a side effect of its ability to repair bone damage. Next, they combined glucosamine with a variety of NSAIDs at a variety of dosages. With several NSAIDs, including naproxen, the addition of glucosamine caused an additive effect, meaning the sum of each drug's properties. When combined with aspirin or acetaminophen, the result was subadditive, or less than the sum of each drug's properties. But when combined with ibuprofen, the researchers found pain relief was enhanced and therefore synergistic. "The next step will be to study this drug combination in clinical trials to see whether it can enhance pain relief or offer pain relief using a lower dose of ibuprofen and therefore a lower risk of side effects," said Cowan. The researchers are also investigating other possible drug combinations for the potential relief of pain. Raffa and Tallarida played a role in the development of Ultracet, a combination of tramadol and acetominophen used in the treatment of pain. And Cowan contributed to the development of buprenorphine which, when combined with naloxone, is used in the treatment of opiate addiction.

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